William, too, has a history of engaging in activism to promote a better culture and conversation around mental illness.
"Waking up every day and feeling sad and going on stage is something that is very hard to describe", she said from her kitchen in Los Angeles. The Prince spoke about how important conversations can be with a friend or family member. You won't be judged.
Suicide is the biggest killer of men under 45 in Britain, and Prince William said seeing the impact of suicide through his work as a an air ambulance helicopter pilot had been a "tipping point" in his decision to campaign on mental health issues.
The video - which had been watched over 500,000 times within hours of its release - is part of the Heads Together campaign, a mental health charity championed by William, his wife Kate and brother, Prince Harry.
Prince William compared mental health to physical health- like his brother, he believes conversation around the topic can save lives. They want people to start talking about their feelings more often, and their message is so important.
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"I didn't know what was wrong with me - I thought this must be part of growing up", he said.
"The challenge that so many people have is not knowing how to take that first step of reaching out to another person for help".
"I am so grateful to speak to you", Gaga tells William. "Harry, Catherine and I really felt this was such an important area that throughout all our charitable work, whether it was the veterans, homelessness, addiction, most of it seemed to stem back to mental health issues", he says.
At the weekend, Prince Harry, 32, revealed he had endured two years of "total chaos" in his late twenties and had sought counselling to help come to terms with the death of his mother, Diana, when he was 12.
It was as he neared 30 that the grief he had suppressed began to "come to the forefront", and he acknowledged that having to deal with his grief in public contributed to his coming "very close to a complete breakdown on numerous occasions".